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Started by cozzer on Nov 30, 2015 11:19:40 PM
Clinical trials are useless

A thread for Stillife to tell us that anecdotal evidence from off of the Internets is better than well-conducted double-blind trials.

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jobi258 - 12 Jan 2016 04:15:53 (#1 of 140)

Here is an interesting clinical trial.

http://www.cordblood.com/stem-cell-research/cord-blood-research/autism

I wonder how they measure efficacy?

Stillife - 12 Jan 2016 13:24:10 (#2 of 140)





well-conducted double-blind trials.



Orchestras and lightning can be 'well-conducted' doesn't mean that they will be any good or safe.

axolotl - 14 Jan 2016 16:49:36 (#3 of 140)

"Clinical trials are useless"

Quite a lot are. See Ben Goldacre's column in the grauniad.

davedanon - 14 Jan 2016 22:50:52 (#4 of 140)

Orchestras and lightning can be 'well-conducted' doesn't mean that they will be any good or safe.

Simply substitute 'organised' or 'constructed' for 'conducted' then, if it's making you confused. Hth.

invicta - 14 Jan 2016 22:57:18 (#5 of 140)

A clinical researcher will probably be around in a minute, if he can be arsed.... (not sure he can, and good on him if so).

Stillife - 15 Jan 2016 16:27:10 (#6 of 140)

Simply substitute 'organised'



Makes me think of more efficient crime. Nmhaa

RosyLovelady - 15 Jan 2016 16:30:02 (#7 of 140)

Bad news of a clinical trial gone horribly wrong. It was also on The World At One earlier today.

http://www.independent.co.uk/news/world/europe/fra
nce-clinical-trial-one-person-brain-dead-and-five-more-in-hospital-after-drug-testing-a6813791.html

Stillife - 15 Jan 2016 16:35:41 (#8 of 140)

Shove this in google

" the covered up deaths of clinical trials"

lots of deaths in third world countries.

That apart my points on this trhread are that even if the trials were perfect , they are releasing novel substances into an imperfect world , with imperfect systems and where people have imperfect bodies

Policywatcher - 15 Jan 2016 16:36:40 (#9 of 140)

Beat me to it, Rosy. Here's the Guardian article on it:

http://www.theguardian.com/world/2016/jan/15/frenc
h-drug-trial-one-person-in-coma-and-five-critically-ill


Only says much the same, though.

tasselhoff - 15 Jan 2016 16:42:41 (#10 of 140)

There's something very fishy about this trial. It's based on cannabinoids that have never really harmed anyone in years. I'm guessing they either synthesised something slightly different in order to be able to patent it (to horrible effect) or its an attempt to shut down all cannabis-related research (as it has multiple beneficial therapeutic uses which could threaten existing markets).

tasselhoff - 15 Jan 2016 16:43:25 (#11 of 140)

Ah:

Marisol Touraine, the French health minister, later said that the pill did not contain cannabis or its derivatives but acted on the body's endocannabinoid system.

tasselhoff - 15 Jan 2016 16:45:07 (#12 of 140)

I heard earlier that it was for pain relief and that there were eight people in the test (but as the early info seems dodgy, I'd take that with a pinch of salt).

fenderstrat - 15 Jan 2016 17:04:12 (#13 of 140)

I expect billers would approve.

RosyLovelady - 15 Jan 2016 17:06:07 (#14 of 140)

< the body's endocannabinoid system >

I didn't know I had one of those. Live and learn.

MrNatural - 16 Jan 2016 02:22:27 (#15 of 140)

Paracetamol acts on the body's endocannabinoid system.

Its other name: Tylenol.

CarlosFandango - 16 Jan 2016 02:26:39 (#16 of 140)

You heard it here first, folks.

MrNatural - 16 Jan 2016 03:38:07 (#17 of 140)

http://www.ncbi.nlm.nih.gov/pubmed/17227290

thisonehasalittlehat - 16 Jan 2016 07:21:51 (#18 of 140)

Ben goldacre hasn't had a column in the guardian for about ten years!

Policywatcher - 16 Jan 2016 19:39:14 (#19 of 140)

http://www.vox.com/2016/1/16/10777050/university-of-maryland-chocolate-milk

Stillife - 17 Jan 2016 13:57:19 (#20 of 140)

Will we ever see a time when GPs will be widely prescribing stuff not manufactured by big pharma?

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